San Francisco, CA
Life Sciences Real Estate in the San Francisco Bay Area Gains Ground in Q2 Against Market Headwinds
Lab space across 12 largest US biotech hubs registered rent increase, vacancy decline despite challenging economy
August 15, 2022

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The Bay Area had the highest demand for lab space (4.4. million sq. ft.) among the 12 largest U.S. life sciences hubs, with average rents in the Bay Area commanding $67.72 per sq. ft., significantly higher than the 12-market average of $54.77 per sq. ft. Vacancy for lab space in the Bay Area was 5.8 percent, slightly above the 5.2 percent average of the 12 largest U.S. life sciences hubs.
Developers sought to boost supply in the region with 5.1 million sq. ft. of new development and conversions, 26 percent of which is pre-leased. Most of the development and conversion activity is focused along the San Francisco Peninsula and Oakland markets, while San Francisco and Silicon Valley are seeing some office and R&D facilities earmarked for future life science development.
“With rising costs of construction and inflation, we’re seeing increased competition for existing lab space, as well as developers delivering improved warm shells as tenants pursue cost-effective strategies,” said Dino Perazzo, Vice Chairman in CBRE’s life sciences practice in the San Francisco Bay Area.
Despite gains in lease rates and construction, venture capital funding has slowed this year, and initial public offerings by life sciences companies have fallen off dramatically amid a broader economic downturn.
“Few, if any, sectors are completely immune to economic cycles. Even so, the life sciences sector is buttressed by more fundamental, long-term shifts than most industries, such as advances in science and technology, expanding uses for biotechnology, and the long-term trend toward more individualized treatment,” said Matt Gardner, CBRE’s Americas Life Sciences Leader. “Indicators and market forces will shift on a quarterly or annual basis, but the underlying science continues to develop and expand.”
Top Life Sciences Markets: Select Q2 Stats
Market | Market Size* | Vacancy | Sq. Ft. Under Construction | Sq. Ft. of Current Tenant Demand |
Boston/Cambridge | 50.5M | 1.2% | 14.9M | 4.2M |
Chicago | 2M | 33.6% | 281,000 | 980,000 |
Denver/Boulder | 4.8M | 4.3% | 616,381 | 1.3M |
Los Angeles | 8.7M | 10.8% | 793,904 | 934,000 |
New Jersey | 20.4M | 7% | 147,000 | 1M |
New York City | 2.5M | 5% | 860,403 | 2M |
Philadelphia | 9.3M | 7.8% | 1.4M | 2M |
Raleigh-Durham | 10.6M | 11.3% | 236,250 | 800,000 |
San Diego | 22.9M | 9.7% | 1.2M | 700,000 |
San Francisco Bay Area | 32.6M | 5.8% | 5.1M | 4.4M |
Seattle | 9.3M | 9.7% | 1.2M | 700,000 |
Washington, DC | 10.7m | 1.4% | 1M | 848,500 |
About CBRE Group, Inc.
CBRE Group, Inc. (NYSE:CBRE), a Fortune 500 and S&P 500 company headquartered in Dallas, is the world’s largest commercial real estate services and investment firm (based on 2024 revenue). The company has more than 140,000 employees (including Turner & Townsend employees) serving clients in more than 100 countries. CBRE serves a diverse range of clients with an integrated suite of services, including facilities, transaction and project management; property management; investment management; appraisal and valuation; property leasing; strategic consulting; property sales; mortgage services and development services. Please visit our website at www.cbre.com.