330 Yale Welcomes UW Medicine’s Institute for Protein Design

CBRE announced it arranged a 31,837 sq. ft. lease to the UW Medicine's Institute for Protein Design (IPD) at 330 Yale, a 211,555 sq. ft. Class A life science facility in Seattle's South Lake Union.

This lease is the first major life science lease in 2025 and will add a preeminent research institution to the South Lake Union life science ecosystem.

"In this competitive Seattle life science market, we couldn’t be more pleased that a leader such as the IPD has chosen to expand into 330 Yale,” said Sam Gillespie, Vice President at K-Star Asset Management, a KKR company. “We hope the investments we have made in the building, including new speculative lab suites and amenities, will help this team transform its basic science breakthroughs into critically needed medicines and more.”

The IPD, led by newly minted Nobel Laureate David Baker, is the world’s leading center for advancing protein design. From life-saving vaccines to sustainable materials, IPD scientists are pioneering entirely new proteins that address challenges in medicine, technology and sustainability.

“With support from the UW Regents, we’re excited to build a new center of excellence for translational science at 330 Yale,” said Baker, who is an HHMI investigator and professor of biochemistry at the University of Washington School of Medicine. “This new space will help us translate ideas from the lab into real world benefits for humanity.”

After taking ownership of the property last year, 330 Yale Owner LLC has since invested in new amenities, including a large 80+ person divisible conference room, rooftop event space and three move-in ready lab suites that will be completed by Q3 2025.

“This new lease is a testament to the strength of Seattle's life science ecosystem," said Yamamoto. "We're thrilled to have IPD select 330 Yale, which has distinguished itself as a top life science facility with the amenities, ownership, and location that current life science companies desire. The Institute will occupy the entire third floor and the property can accommodate future growth with move-ready lab space on the second floor."

Leasing activity in the Seattle life science market has gained strong momentum with increased tenant interest from both established and start-up companies in Q4 2024, according to CBRE Research.

For more information on 330 Yale, click here.